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Magnesium Glycinate vs. Magnesium Bisglycinate: Know the Difference

Shumaila Saeed
By Shumaila Saeed || Updated on December 25, 2023
Magnesium Glycinate is a magnesium salt bonded with one glycine molecule, while Magnesium Bisglycinate contains two glycine molecules bonded to magnesium.
Magnesium Glycinate vs. Magnesium Bisglycinate

Key Differences

Magnesium Glycinate is a compound where magnesium is bonded to the amino acid glycine. This form is typically used for its calming effects on the brain and its efficiency in absorption. Magnesium Bisglycinate, on the other hand, refers to a similar compound where each magnesium ion is bonded to two glycine molecules. This difference in molecular structure can influence the way the body absorbs and utilizes the magnesium.
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Dec 23, 2023
When discussing Magnesium Glycinate, its notable for its high bioavailability and less likelihood to cause laxative effects. This is due to the presence of a single glycine molecule, which facilitates easier digestion and absorption. In contrast, Magnesium Bisglycinate contains an additional glycine molecule, which may enhance the stability of the compound and potentially improve its digestive tolerance, though the difference is often subtle.
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In terms of benefits, Magnesium Glycinate is widely recognized for supporting muscle health, improving sleep quality, and managing stress and anxiety. Its single glycine component also plays a role in neurotransmitter function. Magnesium Bisglycinate, with its double glycine content, is thought to offer similar benefits, but with possibly an added advantage in terms of gut health and gentleness on the digestive system.
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Dec 23, 2023
The choice between Magnesium Glycinate and Magnesium Bisglycinate often comes down to individual tolerance and specific health needs. While both offer the essential benefits of magnesium, the presence of one versus two glycine molecules in Magnesium Bisglycinate can slightly alter its absorption rate and gastrointestinal impact compared to Magnesium Glycinate.
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Comparison Chart

Glycine Molecules

Contains one glycine molecule.
Contains two glycine molecules.
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Bioavailability

High bioavailability.
Similarly high, potentially better.
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Digestive Tolerance

Good, with fewer laxative effects.
Possibly gentler on the digestive system.
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Use Cases

Ideal for sleep, muscle health.
Similar, with potential added gut health benefits.
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Molecular Structure

Simpler molecular structure.
More complex due to extra glycine.
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Magnesium Glycinate and Magnesium Bisglycinate Definitions

Magnesium Glycinate

A compound that combines magnesium with the amino acid glycine.
Magnesium glycinate is effective due to its amino acid component.
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Magnesium Bisglycinate

Used for similar benefits as magnesium glycinate, with added gut health advantages.
Magnesium bisglycinate has improved my gut health significantly.
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Shumaila Saeed
Dec 11, 2023

Magnesium Glycinate

A magnesium salt of glycine used as a dietary supplement.
I take magnesium glycinate to improve my sleep quality.
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Dec 11, 2023

Magnesium Bisglycinate

A form of magnesium that provides efficient magnesium supplementation with minimal side effects.
I switched to magnesium bisglycinate for its minimal side effects.
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Dec 11, 2023

Magnesium Glycinate

Used in supplements for supporting bone health and muscle function.
My doctor recommended magnesium glycinate for my osteoporosis.
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Dec 11, 2023

Magnesium Bisglycinate

Known for its enhanced stability and digestive tolerance.
I prefer magnesium bisglycinate as it's easier on my stomach.
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Dec 11, 2023
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Magnesium Glycinate

A form of magnesium known for its calming effect on the brain.
Magnesium glycinate helps me manage my anxiety.
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Dec 11, 2023

Magnesium Bisglycinate

Magnesium bisglycinate combines essential magnesium with the added benefits of glycine.
My nutritionist suggested magnesium bisglycinate for its dual benefits.
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Dec 11, 2023

Magnesium Glycinate

Magnesium glycinate is popular for its high bioavailability and minimal gastrointestinal side effects.
Since switching to magnesium glycinate, I've had no digestive issues.
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Dec 11, 2023

Magnesium Bisglycinate

A magnesium compound where magnesium is bonded with two glycine molecules.
Magnesium bisglycinate is often recommended for better absorption.
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Dec 11, 2023

Repeatedly Asked Queries

What are the side effects of Magnesium Bisglycinate?

Similar to glycinate, but generally even milder.
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Is Magnesium Glycinate better absorbed than Magnesium Bisglycinate?

Both are well-absorbed, but bisglycinate may offer slightly better absorption.
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Can Magnesium Glycinate cause digestive issues?

It's less likely to cause such issues compared to other forms.
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What are the main uses of Magnesium Glycinate?

For sleep, stress relief, and muscle health.
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Who should take Magnesium Glycinate?

Those needing magnesium supplementation, especially for neurological benefits.
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Does Magnesium Bisglycinate have any special advantages?

Its dual glycine content may offer enhanced benefits for gut health.
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What are the benefits of Magnesium Bisglycinate?

Similar to glycinate, with potential gut health benefits.
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Can Magnesium Glycinate improve sleep?

Yes, it's effective for sleep disorders.
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What is Magnesium Glycinate?

A magnesium salt bonded with glycine, used as a dietary supplement.
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Shumaila Saeed
Dec 23, 2023

What is Magnesium Bisglycinate?

Similar to magnesium glycinate but with two glycine molecules.
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How does Magnesium Glycinate differ from Magnesium Bisglycinate in structure?

Magnesium glycinate has one glycine molecule, bisglycinate has two.
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Is Magnesium Bisglycinate gentler on the stomach?

Yes, its extra glycine may make it gentler.
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Is Magnesium Bisglycinate suitable for children?

Only under medical supervision.
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Can I take Magnesium Glycinate with other medications?

Consult a doctor, as it may interact with some drugs.
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How does Magnesium Glycinate impact bone health?

It supports bone density and health.
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Is Magnesium Glycinate vegan?

Yes, it's typically vegan-friendly.
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Does Magnesium Bisglycinate contain allergens?

Usually allergen-free, but always check product labels.
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Are there any side effects of Magnesium Glycinate?

Rarely, it can cause mild gastrointestinal symptoms.
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Can Magnesium Bisglycinate help with anxiety?

Yes, its calming effect is beneficial for anxiety.
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Who should choose Magnesium Bisglycinate?

People with sensitive digestive systems or requiring higher magnesium doses.
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Dec 23, 2023

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About Author
Shumaila Saeed
Written by
Shumaila Saeed
Shumaila Saeed, an expert content creator with 6 years of experience, specializes in distilling complex topics into easily digestible comparisons, shining a light on the nuances that both inform and educate readers with clarity and accuracy.

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