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Hashimotos vs. Lupus: Know the Difference

Shumaila Saeed
By Shumaila Saeed || Published on February 21, 2024
Hashimoto's is an autoimmune thyroid disorder causing hypothyroidism, symbolizing self-attack, while Lupus is a systemic autoimmune disease affecting multiple organs, signifying widespread inflammation.
Hashimotos vs. Lupus

Key Differences

Hashimoto's, primarily a thyroid-specific autoimmune condition, leads to hypothyroidism, characterized by an underactive thyroid. In contrast, Lupus is a systemic autoimmune disease that can affect any part of the body, including joints, skin, kidneys, heart, lungs, blood vessels, and brain.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024
In Hashimoto's, the immune system specifically targets the thyroid gland, gradually destroying thyroid cells, resulting in decreased thyroid hormone production. Lupus, however, has a broader impact, where the immune system can attack different tissues throughout the body, causing a wide range of symptoms.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024
The symptoms of Hashimoto's are mainly related to the slow metabolic rate due to low thyroid hormone levels, like fatigue, weight gain, and cold intolerance. Lupus symptoms are more diverse and can include joint pain, skin rashes, fever, and organ damage, reflecting its systemic nature.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024
Diagnosis of Hashimoto's typically involves checking for elevated thyroid-stimulating hormone (TSH) levels and antibodies against thyroid peroxidase. In contrast, diagnosing Lupus often requires a combination of blood tests, including antinuclear antibody (ANA) tests, and clinical evaluation of symptoms.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024
Treatment for Hashimoto's usually focuses on hormone replacement therapy to compensate for reduced thyroid function. Lupus treatment, on the other hand, is more complex and may include anti-inflammatory drugs, immunosuppressants, and lifestyle modifications to manage the multifaceted symptoms.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024
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Comparison Chart

Primary Affected Organ

Thyroid gland
Multiple organs (joints, skin, kidneys, heart, lungs, etc.)
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Shumaila Saeed
Feb 21, 2024

Immune System Target

Thyroid cells
Various tissues throughout the body
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Shumaila Saeed
Feb 21, 2024

Main Symptoms

Fatigue, weight gain, cold intolerance
Joint pain, skin rashes, fever, organ damage
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Shumaila Saeed
Feb 21, 2024

Diagnostic Tests

Elevated TSH levels, thyroid antibodies
ANA tests, clinical symptom evaluation
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

Treatment Approach

Hormone replacement therapy
Anti-inflammatory drugs, immunosuppressants
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Shumaila Saeed
Feb 21, 2024
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Hashimotos and Lupus Definitions

Hashimotos

Chronic lymphocytic thyroiditis.
Hashimotos often progresses slowly over years.
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Shumaila Saeed
Jan 16, 2024

Lupus

Diagnosed through a combination of blood tests and symptoms.
Her positive ANA test led to a Lupus diagnosis.
Shumaila Saeed
Shumaila Saeed
Jan 16, 2024

Hashimotos

Autoimmune destruction of the thyroid gland.
Her fatigue was a symptom of Hashimotos.
Shumaila Saeed
Shumaila Saeed
Jan 16, 2024

Lupus

A chronic autoimmune disease affecting multiple body systems.
Lupus can cause severe joint pain and fatigue.
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Shumaila Saeed
Jan 16, 2024

Hashimotos

A leading cause of hypothyroidism.
Many hypothyroid patients are found to have Hashimotos.
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Shumaila Saeed
Jan 16, 2024
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Lupus

Characterized by periods of illness, called flares, and remissions.
She was experiencing a flare-up of her Lupus.
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Shumaila Saeed
Jan 16, 2024

Hashimotos

Characterized by thyroid inflammation.
Thyroid inflammation in Hashimotos can lead to a swollen neck.
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Shumaila Saeed
Jan 16, 2024

Lupus

Can cause widespread inflammation and tissue damage.
The Lupus was affecting her kidneys.
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Shumaila Saeed
Jan 16, 2024

Hashimotos

An autoimmune thyroiditis causing hypothyroidism.
After being diagnosed with Hashimotos, she began taking thyroid medication.
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Shumaila Saeed
Jan 16, 2024

Lupus

A constellation of stars in the Southern Hemisphere near Centaurus and Scorpius.
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Shumaila Saeed
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Lupus

See systemic lupus erythematosus.
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Shumaila Saeed
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Lupus

Any of several other forms of lupus erythematosus.
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Shumaila Saeed
Jan 16, 2024

Lupus

(pathology) Any of a number of autoimmune diseases, the most common of which is systemic lupus erythematosus.
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Shumaila Saeed
Jan 16, 2024

Lupus

Originally, a cutaneous disease with the appearance of the skin having been gnawed, and occurring under two distinct forms. Now used as a generic term for over ten distinguishable diseases having visible cutaneous symptoms.
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Shumaila Saeed
Jan 16, 2024

Lupus

The Wolf, a constellation situated south of Scorpio.
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Shumaila Saeed
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Lupus

Any of several forms of ulcerative skin disease
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Shumaila Saeed
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Lupus

A constellation in the southern hemisphere near Centaurus
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Lupus

Affects more women than men.
Lupus is more common in women, especially of childbearing age.
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Shumaila Saeed
Jan 16, 2024

Repeatedly Asked Queries

What triggers Lupus?

Unknown; possibly genetics, environment, and hormones.
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Shumaila Saeed
Feb 21, 2024

Can Hashimotos be cured?

No cure, but treatable with thyroid hormone therapy.
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Shumaila Saeed
Feb 21, 2024

Is Hashimotos hereditary?

It has a genetic component.
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Shumaila Saeed
Feb 21, 2024

Is Lupus hereditary?

Genetics play a role, but it's not strictly hereditary.
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Shumaila Saeed
Feb 21, 2024

Do men get Hashimotos?

Less common, but possible.
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Shumaila Saeed
Feb 21, 2024

Can Lupus be cured?

No cure, but symptoms can be managed.
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Shumaila Saeed
Feb 21, 2024

How does Lupus affect the body?

Causes widespread inflammation and tissue damage.
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Shumaila Saeed
Feb 21, 2024

What causes Hashimotos?

An autoimmune response against the thyroid gland.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

Is pregnancy safe with Hashimotos?

Yes, with proper thyroid management.
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Shumaila Saeed
Feb 21, 2024

Do men get Lupus?

Less common than in women.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

Is pregnancy safe with Lupus?

Possible, but requires careful medical supervision.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

Can Lupus lead to other health problems?

Yes, like kidney disease, heart problems, and infections.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

Is Lupus life-threatening?

Can be, especially without proper treatment.
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Shumaila Saeed
Feb 21, 2024

Can Hashimotos lead to other illnesses?

Associated with other autoimmune conditions.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

What are common symptoms of Lupus?

Joint pain, rashes, fever, fatigue.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

Is Hashimotos just hypothyroidism?

It's a specific cause of hypothyroidism.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

Is diet important for Hashimotos?

Healthy diet can support thyroid function.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

Is diet important for Lupus?

Can help manage symptoms and overall health.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

What are common symptoms of Hashimotos?

Fatigue, weight gain, cold sensitivity.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

Is Hashimotos more common than Lupus?

Hashimotos is more common.
Shumaila Saeed
Shumaila Saeed
Feb 21, 2024

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About Author
Shumaila Saeed
Written by
Shumaila Saeed
Shumaila Saeed, an expert content creator with 6 years of experience, specializes in distilling complex topics into easily digestible comparisons, shining a light on the nuances that both inform and educate readers with clarity and accuracy.

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