Difference Between
versus

Smooth Endoplasmic Reticulum vs. Rough Endoplasmic Reticulum: Know the Difference

Shumaila Saeed
By Shumaila Saeed || Published on February 10, 2024
Smooth Endoplasmic Reticulum (ER) synthesizes lipids and detoxifies chemicals, lacking ribosomes; Rough ER, studded with ribosomes, synthesizes and processes proteins.
Smooth Endoplasmic Reticulum vs. Rough Endoplasmic Reticulum

Key Differences

Smooth Endoplasmic Reticulum (Smooth ER) is characterized by its lack of ribosomes, giving it a smooth appearance. In contrast, the Rough Endoplasmic Reticulum (Rough ER) is covered with ribosomes, responsible for its rough appearance.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024
The primary function of Smooth ER is lipid synthesis, including steroids and phospholipids. Rough ER, on the other hand, specializes in protein synthesis and processing, thanks to its ribosomes.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024
Smooth ER plays a role in detoxifying drugs and poisons in liver cells. Rough ER modifies proteins by adding carbohydrates (glycosylation) and forming correct structures.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024
In muscle cells, Smooth ER regulates calcium ion concentration, essential for muscle contractions. Rough ER is crucial in secreting proteins like antibodies and hormones.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024
The metabolic processes in Smooth ER include carbohydrate metabolism and conversion of harmful substances. Rough ER is involved in the quality control and dispatch of proteins to different parts of the cell.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024
ADVERTISEMENT

Comparison Chart

Appearance

Lacks ribosomes, smooth surface
Studded with ribosomes, rough appearance
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Primary Function

Lipid synthesis, detoxification
Protein synthesis, processing
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Role in Cells

Calcium regulation, metabolism
Protein modification, quality control
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Significance in Specific Cells

Drug detoxification in liver cells
Protein secretion in various cells
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Molecular Processes

Carbohydrate metabolism, conversion of substances
Glycosylation and correct protein folding
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024
ADVERTISEMENT

Smooth Endoplasmic Reticulum and Rough Endoplasmic Reticulum Definitions

Smooth Endoplasmic Reticulum

Smooth ER is involved in carbohydrate metabolism.
Glycogen is processed in the Smooth ER of liver cells.
Shumaila Saeed
Shumaila Saeed
Jan 11, 2024

Rough Endoplasmic Reticulum

Rough ER assists in protein transportation.
Proteins are sent to the Golgi apparatus from the Rough ER.
Shumaila Saeed
Shumaila Saeed
Jan 11, 2024

Smooth Endoplasmic Reticulum

Smooth ER synthesizes lipids and hormones.
Steroid hormones are produced in the Smooth ER of adrenal cells.
Shumaila Saeed
Shumaila Saeed
Jan 11, 2024

Rough Endoplasmic Reticulum

Rough ER processes and modifies proteins.
Antibodies are modified in the Rough ER of immune cells.
Shumaila Saeed
Shumaila Saeed
Jan 11, 2024

Smooth Endoplasmic Reticulum

It lacks ribosomes on its surface.
The Smooth ER appears less dense under a microscope due to no ribosomes.
Shumaila Saeed
Shumaila Saeed
Jan 11, 2024
ADVERTISEMENT

Rough Endoplasmic Reticulum

Rough ER is involved in protein synthesis.
Insulin is synthesized in the Rough ER of pancreatic cells.
Shumaila Saeed
Shumaila Saeed
Jan 11, 2024

Smooth Endoplasmic Reticulum

It regulates calcium ions in muscle cells.
Smooth ER releases calcium for muscle contraction.
Shumaila Saeed
Shumaila Saeed
Jan 11, 2024

Rough Endoplasmic Reticulum

It has ribosomes on its surface.
The Rough ER appears granular under a microscope due to ribosomes.
Shumaila Saeed
Shumaila Saeed
Jan 11, 2024

Smooth Endoplasmic Reticulum

Smooth ER detoxifies chemicals in liver cells.
Alcohol is detoxified in the Smooth ER of liver cells.
Shumaila Saeed
Shumaila Saeed
Jan 11, 2024

Rough Endoplasmic Reticulum

It plays a role in protein quality control.
Misfolded proteins are identified in the Rough ER.
Shumaila Saeed
Shumaila Saeed
Jan 11, 2024

Repeatedly Asked Queries

What role does Rough ER play in protein synthesis?

It synthesizes and processes proteins.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

What distinguishes Rough ER?

Its surface is studded with ribosomes.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

How does Smooth ER aid in detoxification?

By metabolizing and converting toxic substances.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Can the functions of Smooth and Rough ER overlap?

While distinct, some overlap in functions can occur.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Are SER and RER physically connected in the cell?

Yes, they are interconnected, allowing for efficient transport of molecules between them.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

What is the main function of Smooth ER?

Lipid and hormone synthesis.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Is Smooth ER present in all cells?

It's found in most eukaryotic cells, with varying prominence.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Do both ER types originate from the same membrane network?

Yes, they are continuous parts of the endoplasmic reticulum.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

What is the primary function of RER in cells?

Its primary function is to synthesize and process proteins, particularly those destined for secretion or insertion into membranes.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Can RER be found in plant cells as well as animal cells?

Yes, both plant and animal cells contain RER, though the types of proteins produced may vary.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Are SER and RER essential for cell survival?

Yes, both SER and RER are essential organelles for various cellular processes, and their proper functioning is crucial for cell survival and function.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

What is the role of RER in the endomembrane system?

RER is a key component of the endomembrane system and aids in protein synthesis, folding, and transport within the cell.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Can you find RER in nerve cells?

Yes, nerve cells may contain RER for protein synthesis related to their functions.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

How does calcium regulation in Smooth ER affect muscles?

It triggers muscle contraction and relaxation.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Do SER and RER have distinct functions in maintaining cell homeostasis?

Yes, their functions are distinct; SER is more focused on lipids and detoxification, while RER is primarily involved in protein synthesis.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Which types of cells typically have abundant RER?

Cells actively involved in protein production, like pancreatic and antibody-producing cells, often have abundant RER.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Is RER involved in lipid metabolism like SER?

No, RER primarily focuses on protein synthesis and processing, not lipid metabolism.
Shumaila Saeed
Shumaila Saeed
Feb 10, 2024

Share this page

Link for your blog / website
HTML
Link to share via messenger
About Author
Shumaila Saeed
Written by
Shumaila Saeed
Shumaila Saeed, an expert content creator with 6 years of experience, specializes in distilling complex topics into easily digestible comparisons, shining a light on the nuances that both inform and educate readers with clarity and accuracy.

Popular Comparisons

Trending Comparisons

Poster vs. InfographicPoster vs. Infographic
Shumaila SaeedShumaila Saeed
December 25, 2023
A Poster is a large printed image or notice for public display, while an Infographic is a visual representation of information or data.
FPTP vs. PRFPTP vs. PR
Shumaila SaeedShumaila Saeed
February 16, 2024
FPTP (First Past the Post) is a simple plurality voting system where the candidate with most votes wins; PR (Proportional Representation) allocates seats based on the proportion of votes each party receives.
Japanese Eyes vs. Chinese EyesJapanese Eyes vs. Chinese Eyes
Shumaila SaeedShumaila Saeed
December 25, 2023
Japanese Eyes and Chinese Eyes refer to linguistic structures in Japanese and Chinese respectively, each reflecting unique aspects of grammar and syntax.
2 Pole Motors vs. 4 Pole Motors2 Pole Motors vs. 4 Pole Motors
Shumaila SaeedShumaila Saeed
December 25, 2023
2 Pole Motors have one pair of magnetic poles and run at higher speeds, while 4 Pole Motors have two pairs of poles and operate at lower speeds, offering higher torque.
Login vs. LogonLogin vs. Logon
Shumaila SaeedShumaila Saeed
December 25, 2023
"Login" and "Logon" are often used interchangeably to describe the process of gaining access to a computer system, but "login" can also refer to the credentials used for access.
Poem vs. PoetryPoem vs. Poetry
Shumaila SaeedShumaila Saeed
December 25, 2023
A poem is a piece of writing that expresses ideas and emotions with a distinctive style and rhythm; poetry is the art form of writing such pieces.
Nuclear Family vs. Joint FamilyNuclear Family vs. Joint Family
Shumaila SaeedShumaila Saeed
January 9, 2024
Nuclear Family is a family unit consisting of parents and their children. Joint Family is a larger family structure comprising parents, children, and other relatives living together.
Pulley vs. SheavePulley vs. Sheave
Hifza NasirHifza Nasir
April 4, 2024
A pulley is a wheel on an axle designed to support movement and change of direction of a taut cable, while a sheave is the wheel part of a pulley system that specifically interacts with the cable.
NM3 vs. M3NM3 vs. M3
Hifza NasirHifza Nasir
April 19, 2024
NM3 measures gas volume under Normal conditions (0°C and 1.01325 bar), while M3 measures volume under the conditions at which it is measured, without standard adjustment.
Vital Proteins Collagen vs. OrganikaVital Proteins Collagen vs. Organika
Shumaila SaeedShumaila Saeed
February 9, 2024
Vital Proteins Collagen is a brand offering collagen supplements for health and beauty, while Organika is a broader health and wellness brand with diverse products including collagen.
Pycharm Community vs. Pycharm ProPycharm Community vs. Pycharm Pro
Shumaila SaeedShumaila Saeed
February 4, 2024
PyCharm Community is a free, open-source IDE for Python development, while PyCharm Pro is a paid version with additional advanced features like web development support and database tools.
Slazenger Logo vs. Puma LogoSlazenger Logo vs. Puma Logo
Shumaila SaeedShumaila Saeed
February 15, 2024
The Slazenger logo features a panther, symbolizing agility and tradition, while the Puma logo depicts a leaping puma, representing speed and strength.
Data Roaming vs. Cellular DataData Roaming vs. Cellular Data
Shumaila SaeedShumaila Saeed
December 25, 2023
Data Roaming allows usage of mobile network services outside of the home network area, while Cellular Data is using mobile services within the home network.
Gorilla Glass 3 vs. Gorilla Glass 5Gorilla Glass 3 vs. Gorilla Glass 5
Shumaila SaeedShumaila Saeed
January 1, 2024
Gorilla Glass 3 offers improved scratch resistance and durability compared to its predecessors, while Gorilla Glass 5 focuses on enhanced drop protection and toughness.
Catapult vs. TrebuchetCatapult vs. Trebuchet
Shumaila SaeedShumaila Saeed
January 4, 2024
A catapult is a ballistic device using tension or torsion to launch projectiles, while a trebuchet is a type of catapult using a counterweight for greater force and distance.
Fluid vs. LiquidFluid vs. Liquid
Shumaila SaeedShumaila Saeed
February 13, 2024
Fluids encompass all substances that flow (including gases and liquids), while liquids specifically refer to fluids with a definite volume but no fixed shape, adapting to their container.
DDR3 vs. DDR3LDDR3 vs. DDR3L
Shumaila SaeedShumaila Saeed
January 29, 2024
DDR3 is a type of RAM with standard voltage (1.5V), while DDR3L is a low voltage variant (1.35V) compatible with both 1.5V and 1.35V slots.
Crane vs. HeronCrane vs. Heron
Shumaila SaeedShumaila Saeed
June 24, 2024
Cranes are large, long-legged and long-necked birds known for their elaborate dances, while herons are typically more solitary, stealth hunters with a distinctive S-shaped neck.
Pebble vs. StonePebble vs. Stone
Dua FatimaDua Fatima
May 30, 2024
A pebble is a small, smooth rock worn by water or weather, typically found on beaches or rivers, while a stone is a larger, more varied rock that can be rough or smooth, used in construction or as a tool.
NDM vs. FTPNDM vs. FTP
Shumaila SaeedShumaila Saeed
February 15, 2024
NDM (Network Data Mover) automates and secures data transfers across networks, while FTP (File Transfer Protocol) is a standard network protocol for transferring files between computers.
5'11" vs. 6'0"5’11” vs. 6’0″
Shumaila SaeedShumaila Saeed
February 4, 2024
The difference between 5'11" and 6'0" is one inch, with 5'11" being 71 inches and 6'0" being 72 inches tall.
PPM vs. PPMVPPM vs. PPMV
Shumaila SaeedShumaila Saeed
February 10, 2024
PPM (parts per million) measures the concentration of one substance within a million parts of another. PPMV (parts per million by volume) expresses gas concentration as volume per million volumes of air.
Traditional Trade vs. Modern TradeTraditional Trade vs. Modern Trade
Shumaila SaeedShumaila Saeed
December 25, 2023
Traditional trade involves local, small-scale, often personalized commerce; modern trade is characterized by large-scale, technology-driven, and impersonal retail environments.
Seed vs. GrainSeed vs. Grain
Shumaila SaeedShumaila Saeed
January 24, 2024
A seed is a plant's reproductive unit capable of developing into another plant, while a grain is a type of seed harvested from cereal plants, often used for food.

Featured Comparisons

New Comparisons