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Cyanide vs. Nitrile: Know the Difference

Shumaila Saeed
By Shumaila Saeed || Published on January 15, 2024
Cyanide is a toxic chemical compound containing a carbon-nitrogen bond with a triple bond to a nitrogen atom. Nitrile is an organic compound with a carbon-nitrogen triple bond but connected to an alkyl or aryl group.
Cyanide vs. Nitrile

Key Differences

Cyanide, a highly toxic chemical, is known for its rapid and lethal effects on living organisms due to its ability to inhibit cellular respiration. Nitrile, on the other hand, is an organic compound characterized by a carbon-nitrogen triple bond, commonly used in the production of plastics, rubbers, and pharmaceuticals.
Shumaila Saeed
Shumaila Saeed
Jan 15, 2024
The lethal nature of cyanide stems from its affinity to bind with iron in cytochrome c oxidase of mitochondria, blocking oxygen utilization. Nitriles, while less acutely toxic than cyanides, are important in organic chemistry for their use in synthesizing other compounds and as solvents.
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Shumaila Saeed
Jan 15, 2024
Cyanides are found in various forms, including hydrogen cyanide (HCN) and cyanide salts. Nitriles, differing from cyanides, are stable and versatile organic compounds, often used as intermediates in industrial chemical processes.
Shumaila Saeed
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Jan 15, 2024
Exposure to cyanides can be fatal due to their ability to disrupt key biological processes. Nitriles, while they can be toxic, are more notable for their chemical properties, including stability and reactivity in organic synthesis.
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Shumaila Saeed
Jan 15, 2024
In summary, cyanide's notoriety lies in its high toxicity and potential for use in chemical warfare, whereas nitriles are more recognized for their widespread application in various industrial and pharmaceutical sectors.
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Comparison Chart

Chemical Composition

Carbon-nitrogen bond with nitrogen atom
Carbon-nitrogen triple bond with alkyl or aryl group
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Main Use

Poison, chemical warfare
Industrial manufacturing, pharmaceuticals
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Toxicity

Extremely high, rapidly lethal
Less toxic, varies with structure
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Chemical Stability

Reactive and unstable
Generally stable, useful in organic synthesis
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Common Forms

Hydrogen cyanide, cyanide salts
Acrylonitrile, nitrile rubber
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Cyanide and Nitrile Definitions

Cyanide

Known for its rapid lethal effects through cellular respiration inhibition.
Cyanide poisoning occurs through ingestion, inhalation, or skin absorption.
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Nitrile

Used in producing plastics, rubbers, and pharmaceuticals.
Nitrile is a key ingredient in the production of various drugs.
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Cyanide

A toxic chemical compound with a carbon-nitrogen bond.
Cyanide is used in gold mining to extract gold from ores.
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Nitrile

Stable and versatile in organic synthesis.
Nitrile is frequently used as an intermediate in chemical reactions.
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Cyanide

Found in forms like hydrogen cyanide and cyanide salts.
Hydrogen cyanide is released during house fires, posing a risk to firefighters.
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Nitrile

Less toxic compared to cyanides, varies with structure.
Nitrile compounds are handled with care in chemical labs.
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Cyanide

Used in chemical warfare due to its high toxicity.
Cyanide was historically used in gas form as a chemical weapon.
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Nitrile

An organic compound with a carbon-nitrogen triple bond.
Nitrile gloves are made from synthetic rubber containing nitrile.
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Cyanide

Disrupts key biological processes, leading to rapid fatality.
Cyanide interferes with the body's oxygen utilization, causing death.
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Nitrile

Common forms include acrylonitrile and nitrile rubber.
Acrylonitrile is used in the manufacturing of synthetic fibers.
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Cyanide

The anionic univalent CN group, or any of various salts or esters of hydrogen cyanide containing a CN group, especially the extremely poisonous compounds potassium cyanide and sodium cyanide.
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Nitrile

An organic molecule containing a CN group, an organic derivative of hydrocyanic acid.
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Cyanide

To treat (a metal surface) with cyanide to produce a hard surface.
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Nitrile

An oil-resistant copolymer of acrylonitrile and butadiene, used especially for disposable gloves, gaskets, seals, and tubing. Also called nitrile rubber.
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Cyanide

To treat (an ore) with cyanide to extract gold or silver.
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Nitrile

(organic chemistry) any of a class of organic compounds containing a cyano functional group -C≡N; they are named as derivatives of the appropriate carboxylic acid.
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Cyanide

Any compound containing the -C≡N group or the CN anion.
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Nitrile

A type of synthetic rubber formed by the copolymerisation of acrylonitrile and butadiene.
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Cyanide

(uncountable) Sodium or potassium cyanide, used in the extraction of gold and silver or as a poison.
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Nitrile

Any one of a series of compounds bearing the cyanide radical (-CN); particularly, one of those cyanides of alcohol radicals which, by boiling with acids or alkalies, produce a carboxyl acid, with the elimination of the nitrogen as ammonia.
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Cyanide

(uncountable) Hydrogen cyanide, or cyanide gas, a poisonous gas.
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Nitrile

Any of a class of organic compounds containing the cyano radical -CN
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Cyanide

(transitive) To treat or poison with cyanide.
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Cyanide

A compound formed by the union of cyanogen with an element or radical.
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Cyanide

Any of a class of organic compounds containing the cyano radical -CN
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Cyanide

An extremely poisonous salt of hydrocyanic acid
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Repeatedly Asked Queries

What is Cyanide?

A highly toxic chemical compound with a carbon-nitrogen bond.
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How does Cyanide affect the body?

It inhibits cellular respiration, leading to rapid death.
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Can Cyanide be used in mining?

Yes, especially in gold extraction.
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Are Nitrile compounds toxic?

They can be, but their toxicity is generally lower than cyanides.
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What is Nitrile?

An organic compound with a carbon-nitrogen triple bond.
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Do Nitriles occur naturally?

Rarely, they're mostly man-made.
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How do you detect Cyanide?

Through chemical tests and specific sensors.
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Is Cyanide naturally occurring?

Yes, it's found in certain plants and industrial processes.
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Is Nitrile rubber common?

Yes, it's widely used in gloves and other products.
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Is there an antidote for Cyanide poisoning?

Yes, treatments like hydroxocobalamin counteract its effects.
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Are Cyanide compounds stable?

No, they're reactive and can decompose.
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What is Nitrile used for?

In the production of plastics, rubbers, and pharmaceuticals.
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Can Nitrile be used in organic synthesis?

Yes, it's valuable in chemical reactions.
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Are Cyanides used in pest control?

Yes, but with strict regulations due to toxicity.
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Can Cyanide be used in medicine?

No, due to its high toxicity.
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Is Nitrile soluble in water?

Some are, depending on their structure.
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Can Cyanide be absorbed through the skin?

Yes, especially in its liquid form.
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Are there environmental concerns with Nitrile?

Yes, especially in its disposal and degradation.
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Is Nitrile resistant to chemicals?

Yes, which makes it useful in protective gear.
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What safety precautions are needed for handling Cyanide?

Proper protective equipment and ventilation are essential.
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About Author
Shumaila Saeed
Written by
Shumaila Saeed
Shumaila Saeed, an expert content creator with 6 years of experience, specializes in distilling complex topics into easily digestible comparisons, shining a light on the nuances that both inform and educate readers with clarity and accuracy.

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