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Codon vs. Anticodon: Know the Difference

Shumaila Saeed
By Shumaila Saeed || Published on January 14, 2024
A codon is a sequence of three nucleotides in mRNA that specifies an amino acid or a stop signal during protein synthesis, while an anticodon is a complementary sequence in tRNA that pairs with a codon.
Codon vs. Anticodon

Key Differences

A codon is a fundamental unit in the genetic code, consisting of three consecutive nucleotides on mRNA. Each codon corresponds to a specific amino acid or a stop signal in protein synthesis. Anticodon, on the other hand, is a triplet sequence found on tRNA, crucial for translating mRNA in protein synthesis.
Shumaila Saeed
Shumaila Saeed
Jan 14, 2024
Codons are read during the process of translation in the ribosome, guiding the assembly of amino acids into proteins. In contrast, anticodons play a pivotal role in the recognition process, as each tRNA molecule with its specific anticodon pairs with the corresponding codon on the mRNA strand.
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Jan 14, 2024
In the genetic code, there are 64 codons, each encoding for one of the 20 amino acids or a stop signal. Anticodons, however, do not directly encode anything but instead ensure the correct amino acid is added during protein synthesis by matching with codons.
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The sequence of a codon determines the type of amino acid that will be added next in a growing protein chain. The anticodon, through complementary base pairing, ensures this accuracy by aligning the appropriate tRNA with the mRNA codon.
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Codons are key in dictating the primary structure of proteins, influencing everything from structure to function. Anticodons, by facilitating the correct translation of this genetic information, ensure the proper functioning of proteins within cells.
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Comparison Chart

Location

Found in mRNA
Found in tRNA
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Function

Specifies amino acids or stop signals
Complementary to codon, ensures correct pairing
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Number of Types

64 possible codons
Various anticodons for different tRNAs
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Role in Protein Synthesis

Dictates the sequence of amino acids
Brings the correct amino acid to the ribosome
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Genetic Code Relation

Directly relates to genetic code
Complementary, but not directly coding
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Codon and Anticodon Definitions

Codon

Codons are found in messenger RNA.
MRNA codons are translated during protein synthesis.
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Dec 18, 2023

Anticodon

Anticodons ensure correct protein synthesis.
The anticodon-codon pairing is crucial for accurate translation.
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Codon

A codon is a sequence of three nucleotides in mRNA.
The codon AUG codes for the amino acid methionine.
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Anticodon

An anticodon is part of the tRNA molecule.
Each tRNA anticodon brings a specific amino acid to the ribosome.
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Codon

Codons are the language of the genetic code.
A series of codons in a gene determine the protein sequence.
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Anticodon

An anticodon is a sequence of three nucleotides in tRNA.
The anticodon pairs with its complementary codon in mRNA.
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Codon

A codon is a unit of genetic code.
Each codon translates to a specific amino acid in a protein.
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Dec 18, 2023

Anticodon

Anticodons are complementary to mRNA codons.
The anticodon UAC pairs with the codon AUG.
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Codon

Codons are essential for protein synthesis.
The ribosome reads codons to assemble proteins.
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Anticodon

Anticodons are key in translation.
Anticodons help decode the mRNA message into proteins.
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Dec 18, 2023

Codon

A sequence of three adjacent nucleotides constituting the genetic code that determines the insertion of a specific amino acid in a polypeptide chain during protein synthesis or the signal to stop protein synthesis.
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Anticodon

A sequence of three adjacent nucleotides in transfer RNA that binds to a corresponding codon in messenger RNA and designates a specific amino acid during protein synthesis.
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Codon

A handbell used for summoning monks.
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Anticodon

(genetics) A sequence of three nucleotides in transfer RNA that binds to the complementary triplet (codon) in messenger RNA to specify an amino acid during protein synthesis.
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Codon

The "bell" or flaring mouth of a trumpet.
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Codon

(biochemistry) A sequence of three adjacent nucleotides, which encode for a specific amino acid during protein synthesis or translation.
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Codon

A sequence of three nucleotides in a genome or a DNA or messenger RNA molecule, which specifies the incorporation of one amino acid or is a stop signal, during the biosynthesis of proteins. Codons occur within the protein-coding segments of the DNA or RNA genome of living organisms. The amino acid sequence of proteins synthesized on ribosomes is thus determined by the sequence of the nucleotides in the genome.
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Codon

A specific sequence of three adjacent bases on a strand of DNA or RNA that provides genetic code information for a particular amino acid
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Repeatedly Asked Queries

What is a codon?

A sequence of three nucleotides in mRNA that specifies an amino acid or a stop signal during protein synthesis.
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Jan 14, 2024

How many codons exist?

There are 64 codons.
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What is an anticodon?

A complementary sequence of three nucleotides in tRNA that pairs with a codon.
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Where are anticodons found?

In transfer RNA (tRNA).
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Can a codon code for multiple amino acids?

Generally, one codon codes for one amino acid, but some amino acids are coded by multiple codons.
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How do anticodons function in translation?

They pair with codons to bring the correct amino acid to the ribosome.
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Can anticodons be mutated?

Yes, mutations in tRNA can affect anticodon sequences.
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Do anticodons code for amino acids?

No, they pair with codons to ensure the correct amino acid is added.
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Are anticodons universal?

Yes, they are a universal component of tRNA in all living organisms.
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Do anticodons have a role in genetic regulation?

Indirectly, as they contribute to the accuracy of protein synthesis.
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Where are codons located?

In messenger RNA (mRNA).
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What is the start codon?

AUG, which codes for methionine.
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What is a stop codon?

A codon that signals the end of protein synthesis, like UAA, UAG, or UGA.
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Do anticodons participate in gene expression?

Yes, by facilitating the translation of genes into proteins.
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What happens if an anticodon mismatches a codon?

It can lead to the incorporation of the wrong amino acid, affecting protein function.
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How specific is codon-anticodon pairing?

Highly specific, based on complementary base pairing rules.
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What role do codons play in genetic diseases?

Mutations in codons can lead to incorrect amino acid sequences, causing diseases.
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How are codons read during protein synthesis?

Sequentially, in a 5’ to 3’ direction on mRNA.
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Can an anticodon pair with multiple codons?

Sometimes, due to wobble base pairing.
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Do codons affect protein structure?

Yes, as they determine the amino acid sequence of proteins.
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About Author
Shumaila Saeed
Written by
Shumaila Saeed
Shumaila Saeed, an expert content creator with 6 years of experience, specializes in distilling complex topics into easily digestible comparisons, shining a light on the nuances that both inform and educate readers with clarity and accuracy.

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