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Azithromycin vs. Amoxicillin: Know the Difference

Shumaila Saeed
By Shumaila Saeed || Published on February 4, 2024
Azithromycin is a broad-spectrum macrolide antibiotic, effective against a variety of bacteria, while Amoxicillin is a penicillin-type antibiotic used mainly for bacterial infections.
Azithromycin vs. Amoxicillin

Key Differences

Azithromycin, a macrolide antibiotic, is known for treating a wide range of bacterial infections, including respiratory infections. Amoxicillin, on the other hand, is a penicillin-type antibiotic, commonly used for infections like ear, nose, throat, urinary tract, and skin.
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Shumaila Saeed
Feb 04, 2024
While Azithromycin is effective against certain sexually transmitted infections and respiratory tract infections, Amoxicillin is more frequently used for dental infections and to prevent bacterial endocarditis. Both antibiotics work by stopping the growth of bacteria.
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Azithromycin is often preferred for its once-daily dosing and shorter treatment courses. Amoxicillin, in contrast, requires multiple doses throughout the day and is often prescribed for longer durations, depending on the infection.
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Regarding side effects, Azithromycin may cause mild to severe digestive issues. Amoxicillin can cause allergic reactions in individuals sensitive to penicillin and might lead to antibiotic-associated diarrhea.
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Shumaila Saeed
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Azithromycin's absorption is not significantly affected by food, allowing more flexibility in dosing. Amoxicillin is absorbed faster and more completely when taken on an empty stomach, which can influence how it is administered.
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Comparison Chart

Antibiotic Class

Macrolide
Penicillin
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Common Use

Respiratory infections, STDs
Ear, nose, throat infections, dental infections
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Dosing Frequency

Once daily
Multiple times per day
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Treatment Duration

Short-term (3 to 5 days)
Longer-term (7 to 14 days)
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Food Interaction

Less affected by food
Best absorbed on an empty stomach
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Azithromycin and Amoxicillin Definitions

Azithromycin

A macrolide antibiotic for bacterial infections.
The doctor prescribed Azithromycin for my bronchitis.
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Jan 17, 2024

Amoxicillin

Commonly used for throat and urinary infections.
Her sore throat was treated with Amoxicillin.
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Azithromycin

Known for its once-daily dosing.
Azithromycin's once-daily dosing makes it convenient.
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Amoxicillin

A penicillin-type antibiotic for bacterial infections.
Amoxicillin was given for his ear infection.
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Azithromycin

Can treat certain sexually transmitted diseases.
Azithromycin is often prescribed for chlamydia.
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Amoxicillin

Requires multiple daily doses.
He has to take Amoxicillin three times a day.
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Azithromycin

Effective against a variety of bacterial pathogens.
Azithromycin is used to treat many different types of infections.
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Amoxicillin

Often prescribed for dental infections.
Before dental surgery, she took Amoxicillin.
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Azithromycin

Used in treating respiratory and skin infections.
For her skin infection, Azithromycin was recommended.
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Amoxicillin

Can be used in combination for H. pylori treatment.
Amoxicillin is part of the regimen to treat H. pylori.
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Azithromycin

A macrolide antibiotic, C38H72N2O12, used to treat a variety of bacterial infections.
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Jan 15, 2024

Amoxicillin

A semisynthetic penicillin, C16H19N3O5S, having an antibacterial spectrum of action similar to that of ampicillin.
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Azithromycin

(pharmaceutical drug) A semisynthetic macrolide antibiotic C38H72N2O12 (trademarks Zithromax, Z-PAK) that is derived from erythromycin and is used especially as an antibacterial agent.
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Amoxicillin

(pharmaceutical drug) A moderate-spectrum, bacteriolytic beta-lactam antibiotic C16H19N3O5S closely related to ampicillin and with similar properties, but more readily absorbed when taken orally. It is used to treat bacterial infections caused by susceptible microorganisms.
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Amoxicillin

An antibiotic; a semisynthetic oral penicillin (trade names Amoxil and Larotid and Polymox and Trimox and Augmentin) used to treat bacterial infections
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Repeatedly Asked Queries

How often should Azithromycin be taken?

Typically once daily for a short duration.
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What is Azithromycin?

An antibiotic effective against various bacterial infections.
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Is Amoxicillin safe for children?

Yes, when prescribed by a healthcare provider.
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What is Amoxicillin used for?

Mainly for ear, nose, throat, and dental infections.
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Can I take Amoxicillin for a viral infection?

No, it's ineffective against viruses.
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Is Amoxicillin effective against all bacteria?

No, some bacteria are resistant.
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Can Amoxicillin be used during pregnancy?

It's generally considered safe, but consult a doctor.
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Can Azithromycin treat urinary tract infections?

Yes, it can be used for certain urinary tract infections.
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Is Azithromycin effective against pneumonia?

Yes, it's often used to treat pneumonia.
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Does Azithromycin interact with other medications?

Yes, it can interact with certain drugs.
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Can Azithromycin treat ear infections?

Yes, it's effective for certain ear infections.
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Can Amoxicillin cause allergies?

Yes, especially in those allergic to penicillin.
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How does Azithromycin work?

It stops bacterial growth by interfering with protein synthesis.
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How long does it take for Amoxicillin to work?

Symptoms usually improve within a few days.
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Should Amoxicillin be taken with food?

It's best absorbed on an empty stomach.
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Can Azithromycin treat skin infections?

Yes, it's effective against certain skin infections.
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Is Azithromycin a strong antibiotic?

It's a broad-spectrum antibiotic, effective against various bacteria.
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What are the side effects of Azithromycin?

Commonly, digestive issues.
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What's the difference between Azithromycin and Amoxicillin?

They belong to different antibiotic classes and have different uses.
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Can Amoxicillin treat sexually transmitted infections?

It's not typically used for STDs, except in specific cases.
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About Author
Shumaila Saeed
Written by
Shumaila Saeed
Shumaila Saeed, an expert content creator with 6 years of experience, specializes in distilling complex topics into easily digestible comparisons, shining a light on the nuances that both inform and educate readers with clarity and accuracy.

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