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Amine vs. Amide: Know the Difference

Shumaila Saeed
By Shumaila Saeed || Published on January 12, 2024
Amine is an organic compound derived from ammonia; amide is a compound where an amine group is bonded to a carbonyl group in an organic molecule.
Amine vs. Amide

Key Differences

Amines are organic compounds characterized by the presence of one or more nitrogen atoms bonded to carbon atoms. These compounds are derivatives of ammonia where one or more hydrogen atoms are replaced by organic groups. Amides, on the other hand, are organic compounds containing a carbonyl group (C=O) linked to a nitrogen atom. They are formed from a carboxylic acid and an amine or ammonia, where the carbonyl group of the acid reacts with the nitrogen atom of the amine.
Shumaila Saeed
Shumaila Saeed
Jan 12, 2024
In terms of structure, amines can be primary, secondary, or tertiary, depending on the number of organic groups attached to the nitrogen atom. Primary amines have one, secondary amines two, and tertiary amines three organic groups attached. Amides, however, are classified based on the number of substituents on the nitrogen atom, leading to primary, secondary, or tertiary amides, reflecting the nature of the substituents rather than the number of nitrogen attachments.
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Amines typically have a fishy odor and are found in various biological systems, playing a crucial role in amino acids and neurotransmitters. They exhibit basic properties due to the lone pair of electrons on the nitrogen atom. Amides, while also containing a nitrogen atom, are less basic than amines due to the delocalization of the lone pair of electrons into the carbonyl group, making them more stable and less reactive.
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Shumaila Saeed
Jan 12, 2024
The physical properties of amines vary; lower molecular weight amines are gaseous or liquid at room temperature, while higher molecular weight amines are solid. Amides are generally solid at room temperature, and their melting and boiling points are typically higher than those of corresponding amines due to the presence of stronger intermolecular forces, such as hydrogen bonding.
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Shumaila Saeed
Jan 12, 2024
In practical applications, amines are widely used in the production of pharmaceuticals, dyes, and polymers. They are also important in agricultural chemicals like pesticides. Amides, with their greater stability, find extensive use in the manufacture of plastics, adhesives, and the synthesis of various organic compounds, showcasing the diverse applications of these nitrogen-containing organic compounds.
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Shumaila Saeed
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Comparison Chart

Basic Structure

Nitrogen atom bonded to carbon atoms
Carbonyl group (C=O) linked to nitrogen atom
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Classification

Primary, secondary, tertiary (based on attached organic groups)
Primary, secondary, tertiary (based on substituents on nitrogen)
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Physical State

Gaseous, liquid, or solid (depending on molecular weight)
Generally solid at room temperature
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Odor

Often fishy
Typically odorless or mildly odorous
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Applications

Pharmaceuticals, dyes, polymers, pesticides
Plastics, adhesives, organic synthesis
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Amine and Amide Definitions

Amine

An amine is an organic compound with a nitrogen atom bonded to alkyl or aryl groups.
Methylamine, a simple amine, is used in the synthesis of pesticides.
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Amide

An amide is an organic compound where a nitrogen atom is bonded to a carbonyl group.
Acetamide is used in organic synthesis and as a plasticizer.
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Amine

Amines are characterized by their nitrogen content and are classified based on the number of organic groups attached.
Dimethylamine, a secondary amine, is used in the production of various chemicals.
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Amide

Amides are less reactive than amines due to the delocalization of the nitrogen's lone pair.
Urea, an amide, is widely used as a fertilizer and a feed supplement.
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Amine

Amines are used in the manufacture of dyes, drugs, and polymers.
Aniline, an aromatic amine, is a precursor in dye manufacturing.
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Amide

Amides have higher melting and boiling points compared to amines.
Benzamide, used in organic synthesis, has a high melting point.
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Amine

Amines are derivatives of ammonia with one or more hydrogen atoms replaced by organic groups.
Ethylamine is found in natural processes and industrial applications.
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Amide

Amides are formed from the reaction of carboxylic acids and amines or ammonia.
Nylon, a synthetic polymer, is a type of polyamide.
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Amine

Amines exhibit basic properties and are integral in biological systems.
Dopamine, a neurotransmitter, is a type of bioactive amine.
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Amide

Amides are commonly used in the production of plastics and adhesives.
Polyacrylamide is utilized in water treatment and as a soil conditioner.
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Amine

Any of a group of organic compounds of nitrogen, such as ethylamine, C2H5NH2, that may be considered ammonia derivatives in which one or more hydrogen atoms have been replaced by a hydrocarbon group.
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Amide

An organic compound, such as acetamide, containing the CONH2 group.
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Amine

(inorganic chemistry) A functional group formally derived from ammonia by replacing one, two or three hydrogen atoms with hydrocarbon or other radicals.
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Amide

The anion of ammonia, NH2- or a compound containing this anion, such as sodium amide, NaNH2.
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Amine

(organic chemistry) Any organic compound containing an amine functional group.
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Amide

(organic chemistry) Any derivative of an oxoacid in which the hydroxyl group has been replaced with an amino or substituted amino group; especially such derivatives of a carboxylic acid, the carboxamides or acid amides
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Amine

One of a class of basic substances derived from ammonia by replacement of one or more hydrogen atoms by an alkyl or aryl group. Compare amide, in which an acyl group is attached to the nitrogen. Hydroxylamine and hydrazine, which are not an organic compounds, are also basic and may also be considered amines.
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Amide

(inorganic chemistry) Any ionic derivative of ammonia in which a hydrogen atom has been replaced with a metal cation (R-NH- or R2N-) Category:en:Nitrogen
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Amine

A compound derived from ammonia by replacing hydrogen atoms by univalent hydrocarbon radicals
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Amide

A compound formed by the union of amidogen with an acid element or radical. It may also be regarded as ammonia in which one or more hydrogen atoms have been replaced by an acid atom or radical.
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Amide

Any organic compound containing the group -CONH2
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Repeatedly Asked Queries

What is an amine?

An amine is an organic compound derived from ammonia with one or more hydrogen atoms replaced by organic groups.
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Jan 12, 2024

How are amines classified?

Amines are classified as primary, secondary, or tertiary based on the number of organic groups attached to the nitrogen atom.
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Are amides basic?

Amides are less basic than amines due to the delocalization of the nitrogen's lone pair into the carbonyl group.
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What is the physical state of amides?

Amides are generally solid at room temperature.
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Are amines basic?

Yes, amines are basic due to the lone pair of electrons on the nitrogen atom.
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Can amines form hydrogen bonds?

Yes, amines can form hydrogen bonds due to the presence of a nitrogen atom.
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What is an amide?

An amide is an organic compound with a nitrogen atom bonded to a carbonyl group.
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How are amides classified?

Amides are classified as primary, secondary, or tertiary based on the substituents on the nitrogen atom.
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Do amides have an odor?

Amides are typically odorless or have a mild odor.
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Are amides found in nature?

Yes, amides occur naturally in proteins and other biological molecules.
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What are the physical states of amines?

Amines can be gaseous, liquid, or solid depending on their molecular weight.
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What are common uses of amines?

Amines are used in pharmaceuticals, dyes, polymers, and pesticides.
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Do amines have a distinct odor?

Many amines have a fishy odor.
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What are common uses of amides?

Amides are used in making plastics, adhesives, and in organic synthesis.
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Can amides form hydrogen bonds?

Yes, amides can form strong hydrogen bonds, contributing to their higher melting and boiling points.
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Do amides react with acids?

Amides can react with strong acids, but they are generally more resistant to reactions than amines.
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Is it easy to synthesize amines?

Amines can be synthesized through various chemical reactions and are widely produced.
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Is it easy to synthesize amides?

Amides can be synthesized, typically from carboxylic acids and amines, and are commonly produced in the chemical industry.
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Are amines found in nature?

Yes, amines are found in various biological systems and natural processes.
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Do amines react with acids?

Yes, amines react with acids to form ammonium salts.
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Shumaila Saeed
Written by
Shumaila Saeed
Shumaila Saeed, an expert content creator with 6 years of experience, specializes in distilling complex topics into easily digestible comparisons, shining a light on the nuances that both inform and educate readers with clarity and accuracy.

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